Toronto police said it happened in the area of Midland and Passmore Avenues, south of Steeles Avenue East.
When they arrived, officers located a male victim suffering from serious gunshot wounds. CPR was performed on the victim, but he was later pronounced dead at the scene.
Police say they have no information on possible suspects.
They are advising residents in the area that there will be an “increased police presence” while officers investigate and seek evidence.