In response to the current exacerbation of pediatric hepatitis possibly associated with adenovirusThe Centers for Disease Control and Prevention (CDC) found that current data do not suggest an increase in cases of childhood hepatitis or adenovirus 40/41 since the outbreak began compared to pre-pandem levels of COVID-19, according to the Recent Morbidity and Weekly Mortality Report.
“Data from four major administrative databases were analyzed to assess trends in pediatric hepatitis and the percentage of stool samples positive for type 40/41 adenovirus,” the CDC said.
“Although this ecological analysis cannot definitively confirm or refute a possible association between childhood hepatitis and adenovirus, it provides a useful framework for ongoing research.”
The CDC compared the data during the current hepatitis outbreak period from October 2021 to March 2022 with a baseline before the COVID-19 pandemic, because healthcare search behavior may have changed during 2020- 21 in response to the pandemic.
Atlanta, Georgia, USA – August 28, 2011: Close-up of the sign for the Centers for Disease Control and Prevention. Road sign near Clifton Road 1700 block in Atlanta, Georgia, on Emory University campus. Vertical composition. (iStock)
EXERCISE PILL? RESEARCHERS LOCATE MOLECULE IN BLOOD PRODUCED DURING PROGNOSIS
After pediatric hepatitis cases began to be identified in the United States and the United Kingdom for no apparent reason, the CDC issued sound advice in April 2022 to report additional cases.
They found that many of the cases reported also tested positive for adenovirus type 41, a virus known to cause gastroenteritis but not known to cause hepatitis in children with an intact immune system, according to the body.
“Because neither acute hepatitis of unknown etiology nor type 41 adenovirus is reported in the United States, it is unclear whether either has recently risen above historical levels,” the CDC said.
Thus, the organization analyzed data from four sources: the National Subscription Monitoring Program (NSSP), the Special Edition of the Premier Healthcare Database (PHD-SR), the Organ and Transplant Supply Network (OPTN) and Labcorp.
The NSSP collects electronic health information from emergency departments in each US state and the District of Columbia, representing 71% of non-federal emergency sites in the United States.
Pediatric Cardiologist Ryan Serrano, right, talks to his patient, Richard Barnes, left, and Steve Barnes’s father during an examination Thursday, March 11, 2021, at Riley Hospital for Children. The PHD-SR included records from approximately 1,000 hospitals, and pediatric liver transplant data were obtained from the national registry, which is managed by OPTN. (Fox News)
The PHD-SR included records from approximately 1,000 hospitals, and pediatric liver transplant data were obtained from the national registry, which is managed by OPTN.
Labcorp data included results for stool samples tested for adenovirus types 40/41, but could not tell if the type was type 40 or 41, but the CDC noted that about 90% of all adenovirus cases detected in the United States with gastroenteritis is type 41.
There was no significant difference in hospital-related hepatitis or pediatric emergency visits during the epidemic period from October 2021 to March 2022 compared to the COVID-19 pandemic.
There was also no significant increase in the number of monthly liver transplants or an increase in the percentage of positive samples for 40/41 adenovirus types in October 2021 – March 2022 compared to pre-pandemic levels.
However, the United Kingdom reported an increase in the number of adenovirus-positive stool samples in children aged 1 to 4 years compared to pre-pandemic levels, but the agency noted that the data for the total samples tested in the UK were not available, therefore the true percentage of adenovirus positive samples is unknown.
The Prime Minister of the United Kingdom Boris Johnson is leaving 10 Downing Street as he heads for the House of Commons in London. The UK reported an increase in the number of adenovirus-positive stool samples in children aged 1-4 years compared to pre-pandemic levels, but the agency noted that data on total samples tested in the UK were not available (AP / Alberto Pezzali)
The CDC says the data are limited because the analysis assessed hepatitis trends indirectly through electronic health data, because cases of hepatitis without a clear cause cannot be reported in the United States, so the exact reference is currently unknown.
TEXAS CHILDREN’S HOSPITALS HELP FIGHT LACK OF MOTHER FORMULA WITH MILK GIFT BANKS
They also note that, although liver transplants are “well documented”, there is a two to three month delay period for reporting, so the March 2022 data may be minimal.
In addition, because the COVID-19 pandemic likely altered health search behavior, pre-pandemic data are limited to 2017-2019 and it is unknown whether this data is an accurate basis.
CLICK HERE TO RECEIVE THE FOX NEWS APPLICATION
The CDC also noted that the small sample size may make it difficult to identify small changes in incidence because hepatitis cases are rare.
“Finally, these results are intended to provide an overview of trends in pediatric acute hepatitis of unspecified etiology and adenovirus types 40/41 in the United States and can not be used to infer or disprove a causal link between these two diseases.”